Scientists reveal a hidden second layer of human DNA, showing how genome folding controls genes and influences disease development.

The MCM helicase is broadly bound across the genome, and its phosphorylation is antagonistically regulated by the kinase DDK and the phosphatase RIF1–PP1. TRESLIN–MTBP recognises the phosphorylated ...

The human genome has to be carefully organized so it will fit inside of the nuclei of cells, while also remaining accessible to the cellular machinery that works to express the right genes at the ...

Before a cell can divide, it has to precisely duplicate its entire genetic information. However, the DNA in the cell exists ...

A protein that is involved in determining which enzymes cut or unwind DNA during the replication process has been identified. A protein that is involved in determining which enzymes cut or unwind DNA ...

A study conducted in fruit flies by investigators at the University of Alabama at Birmingham has linked a patient variant of ...

Researchers at the University of Bristol have caught DNA-copying enzymes generating long stretches of genetic code without any template to guide them, a behavior the team calls “doodling.” Published ...

Scientists used a bacterial system called retron to turn DNA into a programmable tool inside living cells, enabling gene ...

Most of the cells in our body carry the genome, and those cells are constantly bombarded with environmental influences including UV rays, pollution, alcohol, and other exposures that can damage the ...

Researchers discovered a kinase-driven phosphorylation switch that activates DNA packaging machinery, aligning nucleosomes at ...